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Two truck drivers have died and a northwest NSW highway is expected to be closed for hours after two road trains collided head on.

Emergency workers were called to a bridge at Brewarrina, east of Bourke, around 7pm on Saturday.

Firefighters are working to control the blaze that ignited when the two heavy vehicles crashed, killing both drivers.

Police said the Kamilaroi Highway is blocked in both directions.

Image: Peter Andrea